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Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study

2019

Introduction: Angiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals. Methods: Data from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence o…

MaleRiskmedicine.medical_specialtyA Longitudinal Cohort Study.- Drugs & aging cilt.36 ss.387-393 2019 [VERONESE N. STUBBS B. SMITH L. MAGGI S. JACKSON S. Soysal P. DEMURTAS J. CELOTTO S. KOYANAGI A. -Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty]Angiotensin-Converting Enzyme InhibitorsLower riskCohort Studies03 medical and health sciencessymbols.namesake0302 clinical medicineInternal medicineWeight LossmedicineHumansPharmacology (medical)Longitudinal Studiescardiovascular diseases030212 general & internal medicinePoisson regressionPropensity ScoreAgedFrailtybusiness.industryConfoundingMiddle AgedOsteoarthritis KneeConfidence intervalcarboxypeptidasecaptoprilinhibitorRelative riskNorth AmericaPropensity score matchingCohortsymbolsFemaleIndependent LivingSelf ReportGeriatrics and Gerontologybusinessdipeptidyl030217 neurology & neurosurgeryCohort studyDrugs & Aging
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